During the Edinburgh International Festival of August 2012 twenty two talks were given at Leith on the Fringe at the Out of the Blue venue. They were free and open to everyone…
Although it is counter-intuitive, sleep and exercise present the brain with similar energy challenges, that of optimal provision of cerebral energy, via the liver. Failure to optimally provision cerebral energy in each of the above events results in chronic metabolic stress, and increased risk of metabolic diseases.
During the nocturnal fast this failure to pre-provision the liver (and therefore the brain), results in chronic activation of the HPA (stress) system and increased risk of metabolic syndrome (diabetes/obesity/heart disease and alzheimer’s disease).
The same ‘liver blind’ approach in sport results in osteoporosis, infertility, increased risk of infections and in American professional footballers increased risk of diabetes from age 35. Italian footballers express 5 times the national average for motor neurone disease.
This talk focuses on the way to optimally provision cerebral energy during exercise and during the nocturnal fast. The Exercise Theory of Relativity takes Einstein’s beautiful formula E = MC2 and reverses it to E = CM2
The Munchies: Humans are natural cannabis signallers (cannabinols) by Mike McInnes
Cannabis signalling regulates cerebral glucose metabolism. Modern dietary culture drives up glucose (hyperglycaemia) and insulin (hyperinsulinism). Each of these Twin Hypers act as independent cannabis signalling systems. Central cannabis signalling inhibits glucose uptake into the brain, causing chronic cerebral hunger (The Munchies).
Modern dietary food culture contributes to chronic cerebral hunger via the Twin Hypers, and to increased cannabinoid signalling, resulting in loss of weight control and obesity. No person need ever to have consumed cannabis in any form, to act as a natural cannabis signaller, and to gain weight as a result.
